Abstract: It is developed an imaging circuit with high integration, low cost, low power consumption and high reliability based on the industrial-grade sCMOS sensor Gsense400BSI in this paper, The circuit uses FPGA as the main control chip, and uses double DDR3 to realize data cache. The circuit envelope size is 70mm×70mm×20mm. In order to reduce the cost and improve the energy efficiency ratio and stability of the circuit, several optimizations were carried out in terms of selecting industrial-grade devices with flight experience, low-power power supply network that can meet the requirements of power supply ripple, and heat dissipation layout of high-power devices.The imaging circuit consumes less than 2W.In the absence of an active cooling module, the circuit works well in orbit.With the temperature rise of the sCMOS sensor not exceeding 0.1℃ during each track of imaging, freeing it from reliance on refrigeration measures in some application areas. Because sCMOS sensors are characterized by high integration, low noise, and high quantum efficiency, which enable the recognition of weak starlight, appropriate exposure time range can be quickly obtained by applying automatic exposure algorithm, the imaging circuit has broad application prospects in the field of commercial space-based astronomical observation.